Single nucleotide polymorphisms as tools in human genetics
نویسندگان
چکیده
منابع مشابه
Single nucleotide polymorphisms as tools in human genetics.
The development of detailed single nucleotide polymorphism (SNP) maps of the human genome coupled with high-throughput genotyping technologies may allow us to unravel complex genetic traits, such as multifactorial disease or drug response, over the next few years. Here we describe the current efforts to identify and characterize the large numbers of SNPs required and discuss the practicalities ...
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Uncovering DNA sequence variations that correlate with phenotypic changes, e.g., diseases, is the aim of sequence variation studies. Common types sequence variations are Single nucleotide polymorphism (SNP, pronounced snip).SNPs are the third-generation molecular marker. SNP represents a DNA sequence variant of a single base pair with the minor allele occurring in more than 1% of a given popula...
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Single-nucleotide polymorphisms (SNPs) provide an abundant source of DNA polymorphisms in a number of eukaryotic species. Information on the frequency, nature, and distribution of SNPs in plant genomes is limited. Thus, our objectives were (1) to determine SNP frequency in coding and noncoding soybean (Glycine max L. Merr.) DNA sequence amplified from genomic DNA using PCR primers designed to c...
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Lymphedema is an abnormal accumulation of interstitial fluid, Introduction due to inefficient uptake and reduced flow, leading to swelling and disability, mostly in the extremities. Hereditary lymphedema usually occurs as an autosomal dominant trait with allelic heterogeneity. : We identified single nucleotide polymorphisms (SNPs) in the FOXC2 Methods gene using dbSNP, analyzed their effect on ...
متن کاملanalysis of single nucleotide polymorphisms ( SNPs ) in In silico human
Lymphedema is abnormal accumulation of interstitial fluid, due to Introduction inefficient uptake and reduced flow, leading to swelling and disability, mostly in the extremities. Hereditary lymphedema usually occurs as an autosomal dominant trait with allelic heterogeneity. We identified single Methods: nucleotide polymorphisms (SNPs) in the FOXC2 gene using dbSNP, analyzed their effect on the ...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2000
ISSN: 1460-2083
DOI: 10.1093/hmg/9.16.2403